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KMID : 0895420060160030245
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Journal of Korean Society of Occupational and Enviromental Hygiene
2006 Volume.16 No. 3 p.245 ~ p.253
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Effects of Occupational Chromium Exposure on Plasma Homocysteine, Folate and Vitamin B12 Concentration
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Kim Ki-Woong
Kim Kyoo-Sang
Park In-Jeong
Kang Seong-Kyu
Oh Sung-Soo
Jeong Hyo-Seok
Chang Sung-Keun
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Abstract
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We evaluated the relations among exposure and urinary levels of Cr, folate, vitamin B12 and Hcy levels in the workers chronically exposure to Cr. Subjects were 104 male employees, 65 workers exposed to Cr in 9 electroplating plants and 39 office workers who had never been occupationally exposed to hazardous substances including Cr. The geometric mean(GM) of Cr in workplace was 0.069±0.101 ㎎/m3 and urinary Cr was 0.483±0.394 ㎎/g creatinine and airborne Cr concentration was significantly correlated to the urinary concentration of Cr(r=0.900, p=0.000). The geometric mean concentration of urinary Cr in control group was 0.301±0.255 ㎎/g creatinine. In comparing the workers exposed to Cr with controls, significantly higher mean plasma levels were found of Hcy(11.3 ±4.9 vs 9.4±4.7 μmol/ℓ, p=0.05), but vitamin B12 levels (181.8±68.7 vs 216.0±64.3 nmol/ℓ, p=0.01) was significantly decreased. Hcy concentrations correlated positively with airborne Cr concentrations(r=0.287, p=0.004) and urinary Cr concentrations(r=0.244, p=0.015) but folate concentrations
correlated negatively with airborne(r=-0.234, p=0.020) and urinary Cr concentrations(r=-0.640, p=0.090), respectively. No correlations were observed between vitamin B12, airborne and urinary Cr concentrations. Also, Hcy concentrations correlated positively with vitamin B12(r=0.295, p=0.0020 and negatively with folate concentrations(r=-0.196, p=0.046). The various biological(i.e. age and serum indicates) or lifestyle factors(i.e. medication, smoking, alcohol and coffee intake), also taken into account as potential confounders, did not influence the correlations found. Thus, this study found evidence that Cr might be associated with elevated plasma levels of Hcy. Furthermore, elevated plasma levels of Hcy were significantly associated with folate and vitamin B12 concentration.
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KEYWORD
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chromium, homocysteine, folate, vitamin B12
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